Clinically representative test beds – whether in vitro, ex vivo and in silico are of paramount importance for advancing therapetuic technologies along the translational bath to becoming approved medical devices. We develop advanced, dynamic in vitro test-beds and simulators that recreate three-dimensional motion, hemodynamics and tissue properties simultaneously. We also use computational tools such as finite element analysis to model performance of devices, optimize device design, and reveal the effect that devices have on the constitutive properties, dynamics and function of the receiving tissue and environment.
Park C, Ozturk C, Roche ET, "", , Vol 33, August 2022, doi: 0.1002/adfm.202206734
L. Rosalia, C. Ozturk, J. Coll-Font, Y. Fan, Y. Nagata, M. Singh, D. Goswami, A. Mauskapf, S. Chen, R. A. Eder, E. M. Goffer, J. H. Kim, S. Yurista, B. P. Bonner, A. N. Foster, R. A. Levine, E. R. Edelman, M. Panagia, J. L. Guerrero, E. T. Roche, C. T. Nguyen,"A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis", Nature Biomedical Engineering, 2022, doi: https://doi.org/10.1038/s41551-022-00937-8
Y Fan, J Coll-Font, M ven den Boomen, JH Kim, S Chen, RA Edar, ET Roche, C Nguyen, Frontiers in Physiology, 19 July 2021, doi: 10.3389/fphys.2021.694940
L. Rosalia, C Ozturk, ET Roche, , 13 February 2021, DOI: 10.3791/62167
Roche ET, Shirazi RN, Weafer F, McHugh PE. Computational Modelling of Therapy Pharnacokinetics into Ischemic Heart Tissue from an Implantable Reservoir Delivery System, Bioengineering in Ireland Conference, Belfast, January 20th 2017