Clinically representative test beds – whether in vitro, ex vivo and in silico are of paramount importance for advancing therapetuic technologies along the translational bath to becoming approved medical devices. We develop advanced, dynamic in vitro test-beds and simulators that recreate three-dimensional motion, hemodynamics and tissue properties simultaneously. We also use computational tools such as finite element analysis to model performance of devices, optimize device design, and reveal the effect that devices have on the constitutive properties, dynamics and function of the receiving tissue and environment.
 

Selected Publications

Park C, Ozturk C, Roche ET, "Computational Design of a Soft Robotic Myocardium for Biomimetic Motion and Function", Advanced Functional Materials, Vol 33, August 2022, doi: 0.1002/adfm.202206734

L. Rosalia, C. Ozturk, J. Coll-Font, Y. Fan, Y. Nagata, M. Singh, D. Goswami, A. Mauskapf, S. Chen, R. A. Eder, E. M. Goffer, J. H. Kim, S. Yurista, B. P. Bonner, A. N. Foster, R. A. Levine, E. R. Edelman, M. Panagia, J. L. Guerrero, E. T. Roche, C. T. Nguyen,"A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis", Nature Biomedical Engineering, 2022, doi: https://doi.org/10.1038/s41551-022-00937-8

Y Fan, J Coll-Font, M ven den Boomen, JH Kim, S Chen, RA Edar, ET Roche, C Nguyen, Characterization of Exercise-Induced Myocardium Growth Using Finite Element Modeling and Bayesian Optimization, Frontiers in Physiology, 19 July 2021, doi: 10.3389/fphys.2021.694940

L. Rosalia, C Ozturk, ET Roche, Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction, Journal of Visualized Experiments (JoVE), 13 February 2021, DOI: 10.3791/62167

Roche ET, Shirazi RN, Weafer F, McHugh PE. Computational Modelling of Therapy Pharnacokinetics into Ischemic Heart Tissue from an Implantable Reservoir Delivery System, Bioengineering in Ireland Conference, Belfast, January 20th 2017