Publications

L Hu, D Gau, J Dixon, M Klein, Y Fan, G Menary, ET Roche, Precurved, Fiber-Reinforced Actuators Enable Pneumatically Efficient Replication of Complex Biological Motions, Soft Robotics (SoRo), 17 May 2021 DOI: 10.1089/soro.2020.0087

S. Maglio, C. Park, S. Tognarelli, A. Menciassi, E. T. Roche, High-Fidelity Physical Organ Simulators: From Artificial to Bio-Hybrid Solutions, IEEE Transactions on Medical Robotics and Bionics, 04 Mar 2021 DOI: 10.1109/TMRB.2021.3063808

Gollob SD, Park C, Koo BH, Roche ET. A Modular Geometrical Framework for Modelling the Force-Contraction Profile of Vacuum-Powered Soft Actuators. Frontiers in Robotics and AI. 2021 Mar 03; 8:15. DOI: 10.3389/frobt.2021.606938

L Rosalia, C Ozturk, ET Roche, Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction, Journal of Visualized Experiments (JoVE), 13 Feb 2021, DOI: 10.3791/62167

Luca Rosalia, Caglar Ozturk, David Van Story, Markus Horvath, Ellen T Roche, Object-oriented lumped-parameter modeling of the cardiovascular system for physiological and pathophysiological conditions, Advanced Theory and Simulations, 12 February 2021: Vol. 4, Issue 2, doi: https://doi.org/10.1002/adts.202000216

Roche, Ellen T. A protein sandwich enables real-time in vivo biomarker measurement, Science Translational Medicine  06 Jan 2021: Vol. 13, Issue 575, eabg1758, DOI: 10.1126/scitranslmed.abg1758  Editors Choice Article  Link

    Roche, Ellen T. Encapsulating a leukemia vaccine, Science Translational Medicine  28 Oct 2020: Vol. 12, Issue 567, eabf2642 DOI: 10.1126/scitranslmed.abf2642 Link

     

    Roche, Ellen T. Catheters gain arrays of sensors and actuators, Nature Biomedical Engineering, 22 October 2020, Volume 4, pages 939-940. Link

    Deng J, Yuk H, Wu J, Varela CE, Chen X, Roche ET, Guo CF, Zhao X. Electrical bioadhesive interface for bioelectronics. Nature Materials. 2020 Sep 28:1-8. DOI:10.1038/s41563-020-00814-2

    Roche ET, Shedding light on heart failure, Science Translational Medicine,  02 Sep 2020: Vol. 12, Issue 559, eabe4436 DOI: 10.1126/scitranslmed.abe443

    Roche ET, Minimally Invasive Delivery of Tissue Engineered Heart Valves to the Pulmonary Annulus,  JACC: Basic to Translational Science, 5;8;2020, DOI: 10.1016/j.jacbts.2020.07.001

    Roche ET, Paving the path to inpatient printingScience Translational Medicine  08 Jul 2020:Vol. 12, Issue 551, eabd3082, DOI: 10.1126/scitranslmed.abd3082

    Duffy GP, Robinson ST, O'Connor R, Wylie R, Mauerhofer C, Bellavia G, Straino S, Cianfarani F, Mendez K, Beatty R, Levey R, Duffy GP, Roche ET*, Dolan EB* .Therapeutic Reservoirs: Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models. Advanced Healthcare Materials. 2020 Jun 10;9(11):2070035. DOI: 10.1002/adhm.202070035 (*co-senior authors).

    Horvath MA, Hu L, Mueller T, Hochstein J, Rosalia L, Hibbert KA, Hardin CC, Roche ET. An organosynthetic soft robotic respiratory simulator. APL Bioengineering. 2020 Jun 1;4(2):026108. DOI: 10.1063/1.5140760

    Roche ET. Shedding light on venous thromboembolismScience Translational Medicine,  13 May 2020:Vol. 12, Issue 543, eabb7098, DOI: 10.1126/scitranslmed.abb7098

    Roche ET. Not “dust” any neural stimulator. Science Translational Medicine. 2020 Mar 18;12(535). DOI: 10.1126/scitranslmed.abb2775

    Park C, Fan Y, Hager G, Yuk H, Singh M, Rojas A, Hameed A, Saeed M, Vasilyev NV, Steele TW, Zhao X, Nguyen CT*, Roche ET*. An organosynthetic dynamic heart model with enhanced biomimicry guided by cardiac diffusion tensor imaging. Science Robotics. 2020 Jan 29;5(38). DOI: 10.1126/scirobotics.aay9106.

    Cobi AC, Gray L, Mittmann ER, Link SB, Hanumara NC, Lyatskaya Y, Roche E, Slocum AH, Zygmanski P. Design of a Reconfigurable Quality Assurance Phantom for Verifying the Spatial Accuracy of Radiosurgery Treatments for Multiple Brain Metastases. Journal of Medical Devices. 2019 Dec 1;13(4). DOI: 10.1115/1.4044402

    Yuk H*, Varela CE*, Nabzdyk CS, Mao X, Padera RF, Roche ET, Zhao X. Dry double-sided tape for adhesion of wet tissues and devices. Nature. 2019 Nov;575(7781):169-74. DOI: /10.1038/s41586-019-1710-5 (*co-first authors).

    Fan Y, Ronan W, Teh I, Schneider JE, Varela CE, Whyte W, McHugh P, Leen S, Roche E. A comparison of two quasistatic computational models for assessment of intramyocardial injection as a therapeutic strategy for heart failure. International Journal for Numerical Methods in Biomedical Engineering. 2019 Sep;35(9):e3213. DOI: 10.1002/cnm.3213

    Weafer FM, Duffy S, Machado I, Gunning G, Mordasini P, Roche E, McHugh PE, Gilvarry M. Characterization of strut indentation during mechanical thrombectomy in acute ischemic stroke clot analogs. Journal of neurointerventional surgery. 2019 Sep 1;11(9):891-7. DOI: 10.1136/neurintsurg-2018-014601

    Dolan EB, Varela CE, Mendez K, Whyte W, Levey RE, Robinson ST, Maye E, O’Dwyer J, Beatty R, Rothman A, Fan Y. An actuatable soft reservoir modulates host foreign body response. Science Robotics. 2019 Aug 28;4(33):eaax7043. DOI: 10.1126/scirobotics.aax7043

    Shirazi RN, Islam S, Weafer FM, Whyte W, Varela CE, Villanyi A, Ronan W, McHugh P, Roche ET. Multiscale Experimental and Computational Modeling Approaches to Characterize Therapy Delivery to the Heart from an Implantable Epicardial Biomaterial Reservoir. Advanced healthcare materials. 2019 Aug 22;8(16):1900228. DOI: 10.1002/adhm.201900228

    Varela CE, Fan Y, Roche ET. Optimizing Epicardial restraint and reinforcement following myocardial infarction: Moving towards localized, biomimetic, and multitherapeutic options. Biomimetics. 2019 Mar;4(1):7. DOI: 10.3390/biomimetics4010007

    Roche ET. Implanted device enables responsive bladder control. Nature. 2019 Jan 1;565(7737):298-. DOI: 10.1038/d41586-018-07811-1

    *Horvath MA, *Varela CE, *Dolan EB, Whyte W, Monahan DS, Payne CJ, Wamala IA, Vasilyev NV, Pigula FA, Mooney DJ, Walsh CJ, Roche ET. Towards alternative approaches for coupling of a soft robotic sleeve to the heart. Annals of biomedical engineering. 2018 Oct 15;46(10):1534-47. DOI: 10.1007/s10439-018-2046-2 (*co-first authors)

    Whyte W*, Roche ET*, Varela CE, Mendez K, Islam S, O’Neill H, Weafer F, Shirazi RN, Weaver JC, Vasilyev NV, McHugh PE, Murphy B, Duffy GP, Walsh CJ**, Mooney DJ**. Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir. Nature biomedical engineering. 2018 Jun;2(6):416. DOI: 10.1038/s41551-018-0247-5. (*co-first authors, **co-senior authors)

     

    Wamala I, Roche ET, Pigula FA. The use of soft robotics in cardiovascular therapy. Expert review of cardiovascular therapy. 2017 Oct 3;15(10):767-74. DOI: 10.1080/14779072.2017.1366313

    Payne CJ, Wamala I, Abah C, Thalhofer T, Saeed M, Bautista-Salinas D, Horvath MA, Vasilyev NV, Roche ET, Pigula FA, Walsh CJ. An implantable extracardiac soft robotic device for the failing heart: mechanical coupling and synchronization. Soft robotics. 2017 Sep 1;4(3):241-50. DOI: 10.1089/soro.2016.0076

    Horvath MA, Wamala I, Rytkin E, Doyle E, Payne CJ, Thalhofer T, Berra I, Solovyeva A, Saeed M, Hendren S, Roche ET. An intracardiac soft robotic device for augmentation of blood ejection from the failing right ventricle. Annals of biomedical engineering. 2017 Sep 1;45(9):2222-33. DOI: 10.1007/s10439-017-1855-z

    Roche ET, Horvath MA, Wamala I, Alazmani A, Song SE, Whyte W, Machaidze Z, Payne CJ, Weaver JC, Fishbein G, Kuebler J. Soft robotic sleeve supports heart function. Science translational medicine. 2017 Jan 18;9(373):eaaf3925. DOI: 10.1126/scitranslmed.aaf3925

    O'Neill HS, Gallagher LB, O'Sullivan J, Whyte W, Curley C, Dolan E, Hameed A, O'Dwyer J, Payne C, O'Reilly D, Ruiz‐Hernandez E. Biomaterialenhanced cell and drug delivery: lessons learned in the cardiac field and future perspectives. Advanced materials. 2016 Jul;28(27):5648-61. DOI: 10.1002/adma.201505349

    Cezar CA, Roche ET, Vandenburgh HH, Duda GN, Walsh CJ, Mooney DJ. Biologic-free mechanically induced muscle regeneration. Proceedings of the National Academy of Sciences. 2016 Feb 9;113(6):1534-9. DOI: 10.1073/pnas.1517517113

    Roche ET, Fabozzo A, Lee Y, Polygerinos P, Friehs I, Schuster L, Whyte W, Berazaluce AM, Bueno A, Lang N, Pereira MJ. A light-reflecting balloon catheter for atraumatic tissue defect repair. Science Translational Medicine. 2015 Sep 23;7(306):306ra149-. DOI: 10.1126/scitranslmed.aaa2406

    Hastings CL, Roche ET, Ruiz-Hernandez E, Schenke-Layland K, Walsh CJ, Duffy GP. Drug and cell delivery for cardiac regeneration. Advanced drug delivery reviews. 2015 Apr 1;84:85-106. DOI: 10.1016/j.addr.2014.08.006

    Roche ET, Hastings CL, Lewin SA, Shvartsman DE, Brudno Y, Vasilyev NV, O'Brien FJ, Walsh CJ, Duffy GP, Mooney DJ. Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart. Biomaterials. 2014 Aug 1;35(25):6850-8. DOI: 10.1016/j.biomaterials.2014.04.114

    Isakov A, Murdaugh KM, Burke WC, Zimmerman S, Roche E, Holland D, Einarsson JI, Walsh CJ. A new laparoscopic morcellator using an actuated wire mesh and bag. Journal of Medical Devices. 2014 Mar 1;8(1). DOI: 10.1115/1.4026294

    Roche ET, Wohlfarth R, Overvelde JT, Vasilyev NV, Pigula FA, Mooney DJ, Bertoldi K, Walsh CJ. A bioinspired soft actuated material. Advanced Materials. 2014 Feb;26(8):1200-6. DOI: 10.1002/adma.201304018

    Wan Q, Schoppe O, Gunasekaran S, Holland D, Roche E, Hur HC, Walsh C. Multifunctional Laparoscopic Trocar With Built-in Fascial Closure and Stabilization. Journal of Medical Devices. 2013 Sep 1;7(3). DOI: 10.1115/1.4024478

    Pardo-Martin C, Duffy M, Hoffman K, Poddar R, Holland D, Roche E, Walsh C, Loughlin K. Minimally Invasive Device for Rapid Urethrovesical Anastomosis. Journal of Medical Devices. 2013 Sep 1;7(3). DOI: 10.1115/1.4024503

    Frech AJ, Orozco D, Davoudi K, Ding C, Field R, Yasin R, Roche E, Holland D, Walsh C. Laparoscopic Device for Direct and Indirect Suction. Journal of Medical Devices (technical brief). 2013 Sep 1;7(3). DOI: 10.1115/1.4024519

    O'Flynn PM, Roche ET, Pandit AS. Generating an ex vivo vascular model. Asaio Journal. 2005 Jul 1;51(4):426-33. DOI: 10.1097/01.mat.0000170629.92765.bb

    Teodorescu DL, Reeves CA, McGarel S, Mehra M, Roche ET. “Modulating Left Ventricular Assist Device Driveline Exit Site Biomechanics: A Systematic Approach To Achieving Percutaneous Implant Forgettability”, American Society of Artificial Internal Organs 66th Annual Conference. Virtual Meeting.

    Horvath MA, Hu L, Mueller T, Roche ET. “Design and Fabrication of an In Vitro Model of Human Respiration Based on Soft Biomimetic Mechanisms”. 3rd Institute for Electrical and Electronic Engineers International Conference on Soft Robotics (RoboSoft). Virtual Meeting.

    Ozturk C, Rosalia L, Nguyen CT, Roche ET. “Computational Modeling of a Novel Soft Robotic Implant for Pressure Overload-Induced Heart Failure”. 3rd Institute for Electrical and Electronic Engineers International Conference on Soft Robotics (RoboSoft). Virtual Meeting.

    Mendez K, Whyte W, Duffy GP, Roche ET. "SoftSwitch: A Soft Implantable Device for On/Off Drug Release". Hamlyn Symposium on Medical Robotics, London, England.

    Park C, Roche ET. “Development of an Organosynthetic Left Ventricle”. American Society of Artificial Organs. San Francisco, CA. 

    Weafer F, Roche ET, McHugh PE, Gilvarry M. “Characterisation of Strut Indentation During Mechanical Thrombectomy in Acute Ischemic Stroke Clot Analogues”. Bioengineering in Ireland Conference, Belfast, Nothern Ireland.

    Whyte W, Roche ET. “Therepi: An Implantable System Enabling Targeted Cardiac Therapy with a Replenishable, Epicardial Reservoir”. World Congress of Biomechanics. Dublin, Ireland.

    Dolan EB, Horvath MA, Varela CE, Roche ET. “In Vivo Comparison of a Silicone and Mesh-Based Device-Tissue Interface for Extracardiac Devices”. World Congress of Biomechanics. Dublin, Ireland.

    Hu L, Saaed M, Wamala I, Payne CJ, VanStory D, Roche ET, Vasilyev NV. “Development of a Foldable, Self-Assembling, Structural Brace for a Soft Robotic Assist Device. American Society of Artificial Organs Conference, Philadelphia, PA. 

    Fan Y, Ronan W, McHugh PE, Roche ET. “A Comparison of Two Dynamic Computational Models for Cardiac Mechanics and Assessment of Intra-Myocardial Injection as a Therapeutic Strategy for Heart Failure”. World Congress of Biomechanics. Dublin, Ireland.

    Weafer F, Mc Hugh PE, Roche ET. Therapy transport into ischemic heart tissue from an implantable therapy reservoir device. European Advanced Materials Congress, Stockholm. 2017 Aug 22. Winner of International Association of Advanced Materials Scientist Medal, 2017 area of ‘Biomaterials and Biodevices’

    Payne CJ, Wamala I, Abah C, Thalhofer T, Saeed M, Bautista-Salinas D, Horvath MA, Vasilyev NV, Roche ET, Pigula FA, Walsh CJ. Wearable Soft Robotic Device Supports the Failing Heart in vivo. Hamlyn Symposium on Medical Robotics. 2017 Jun 25 (p. 37). DOI: 10.31256/hsmr2017.19

    Weafer F, Roche ET, McHugh P, Gilvarry M. Characterisation of Strut Indentation during Mechanical Thrombectomy in Acute Ischemic Stroke Clot Analogues. Bioengineering in Ireland Conference, Belfast. 2017 Jan 20.

    Roche ET, Shirazi RN, Weafer F, McHugh PE. Computational Modelling of Therapy Pharnacokinetics into Ischemic Heart Tissue from an Implantable Reservoir Delivery System. Bioengineering in Ireland Conference, Belfast. 2017 Jan 20

    Whyte W, Roche ET, O'Neill H, Duffy GP, Walsh CJ, Mooney DJ. A Replenishable Cell Delivery System for the Heart. 4th TERMIS World Congress, Tissue Engineering Part A. 2015 Sep 1;21(S1):S-1. DOI: 10.1089/ten.tea.2015.5000.abstracts

    Roche ET, Horvath MA, Alazmani A, Galloway KC, Vasilyev NV, Mooney DJ, Pigula FA, Walsh CJ. Design and fabrication of a soft robotic direct cardiac compression device. ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference 2015 Aug 5. American Society of Mechanical Engineers Digital Collection.

    Horvath MA, Roche ET, Vogt DM, Mooney DJ, Pigula FA, Walsh CJ. Soft pressure sensing sleeve for direct cardiac compression device. ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference 2015 Aug 5. American Society of Mechanical Engineers Digital Collection. DOI: 10.1115/DETC2015-47567

    Fabozzo A*, Roche ET*, Lee Y, Polygerinos P, Friehs I, Schuster L, Casar Berazaluce AM, Bueno A, Lang N, Pereira M, Feins E, Wassermann S, O’Cearbhaill ED, Vasilyev NV, Mooney DJ, Karp JM, del Nido, PJ, Walsh CJ. Enabling minimally invasive atraumatic repair of intracardiac septal defects with light. American Association for Thoracic Surgery (AATS) Annual Meeting. 2015 Jul. (*co-first author)

    Roche ET, Wamala I, Horvath M, Song, SE, Vasilyev NV, Machaidze Z, Mooney DJ, Walsh CJ, Pigula FA. Soft Robotic Synchronized Actuation Improves Cardiac Output in a Porcine Model of Heart Failure. Harvard Medical School Research Day, Boston. 2015 May.

    Hameed A, Hastings C, Roche E, O'Brien F, Walsh C, Mooney D, Duffy G. Advanced Materials For Cardiac Regeneration (AMCARE): Improving Stem Cell Delivery to the Infarcted Heart Using Biomaterial Approaches. Irish Journal of Medical Science 2014 Sep 1 (Vol. 183, pp. S246-S246).

    Roche ET, Hastings CL, Lewin SA, Shvartsman D, Brudno YB, Walsh CJ, O’Brien FJ, Duffy GP, Mooney DJ. The promise of biomaterials for improving retention of cells in the infarcted heart. Cell research foundation conference on cell therapy for cardiovascular disease. 2014 Jan. (oral presentation)

    Roche ET, Wohlfarth R, Overvelde JTB, Vasilyev NV, Pigula FA, Mooney DJ, Bertoldi K, Walsh CJ. A Bioinspired Soft Actuated Material. Materials Research Society, Fall Meeting. 2013 Nov.

    Roche ET, Hastings CL, Lewin SA, Shvartsman D, Brudno YB, Walsh CJ, O’Brien FJ, Duffy GP,Mooney DJ. Biomaterials improve retention of cells in the infarcted heart. AHA Conference and abstract in Circulation 2013 Nov 26; 128: A18338

    Roche ET, Menz A, Hiremath P, Vasilyev N, Walsh C. Design and fabrication of a soft, anatomically accurate, patient-specific cardiac simulator with sensing and controls. International Workshop on Soft Robotics and Morphological Computation, Switzerland. 2013 Aug.

    Obiajulu SC, Roche ET, Pigula FA, Walsh CJ. Soft pneumatic artificial muscles with low threshold pressures for a cardiac compression device. ASME 2013 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference 2013 Aug 4. American Society of Mechanical Engineers Digital Collection. DOI: 10.1115/DETC2013-13004

    Orozco D, Davoudi K, Ding C, Field R, Yasin R, Roche ET, Holland D, Walsh CJ. Laparoscopic tool with adjustable sponge at distal tip for direct/indirect suction modulation. Journal of Medical Devices (technical brief). 2013; 7(3):030908-030908-3.MED-13-1044.

    Murdaugh K, Isakov A, Burke WC, Zimmerman S, Roche ET, Holland D, Einarsson JI, Walsh CJ. Faster and Safer Laparoscopic Morcellation Using an Actuated Wire Mesh and Bag. ASME Design of Medical Devices Conference (extended abstract, poster), Minneapolis, Minnesota, USA. 2013 Apr 9-11

    Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey M. Karp, Yuhan Lee, Pedro J. Del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman. "Catheter Device for Transmitting and Reflecting Light " US Patent No. US10,588,695

    Clara Park, Xuanhe Zhao, Hyunwoo Yuk, Christopher T. Nguyen, Ellen T. Roche.  "An Organosynthetic Dynamic Heart Model", Provisional Patent Application 63/021,014 

     

    US Patent 10,058,647 B2 (grant) Biomimetic actuation device and system andmethods for controlling a biomimetic actuation device and system. Issued August 28th 2018.

    Ellen T. Roche, Steven Obiajulu, Conor J. Walsh, David J. Mooney, Frank A. Pigula. "Biomimetic Actuation Device and System, and Methods for Controlling a Biomimetic Actuation Device and System", US Patent No. US10058647B2

    Christine A. Cezar, Conor J. Walsh, David J. Mooney, Ellen T. Roche, Herman H. Vandenburgh, Georg N. Duda. "Compositions and Methods of Mechanically Inducing Tissue Regeneration", US National Phase Application PCT/US2016/062685

    Ellen T. Roche, Kevin O'Sullivan. "Perfusion Dilation Catheter System and Methods of Use", US Patent No. US9480823B2

    Lisa Weldon, Greg Hyde, Ellen T. Roche, Maithili Shrivastava, "Apparatus and System for Measuring of Particles Generated from Medical Devices or Instruments Utilized During Simulated Clinical Applications", US Patent No. US7591198B2. Issued February 2009.