Publications
Keegan Mendez, William Whyte, Benjamin R. Freedman, Yiling Fan, Claudia E. Varela, Manisha Singh, Juan C. Cintron-Cruz, Sandra E. Rothenbücher, Jianyu Li, David J. Mooney, Ellen T. Roche. Mechanoresponsive Drug Release from a Flexible, Tissue-Adherent, Hybrid Hydrogel Actuator. Advanced Materials. https://doi.org/10.1002/adma.20230330
Dillon, T.M., Liang, P., Schermerhorn, M.L. , Roche, E.T. A computational program for automated surgical planning of fenestrated endovascular repair. Commun Eng 2, 37 (2023). https://doi.org/10.1038/s44172-023-00083-2
Samuel Dutra Gollob, Mijaíl Jaén Mendoza, Bon Ho Brandon Koo, Esteban Centeno, Emir A. Vela and Ellen T. Roche. Front. Robot. AI, Sec. Soft Robotics, Volume 10 - 2023 | https://doi.org/10.3389/frobt.2023.1190387
D. Quevedo-Moreno and E. T. Roche, "Design and Modeling of Fabric-Shelled Pneumatic Bending Soft Actuators," in IEEE Robotics and Automation Letters, vol. 8, no. 6, pp. 3110-3117, June 2023, doi: 10.1109/LRA.2023.3264734.
Luca Rosalia et al. ,Soft robotic patient-specific hydrodynamic model of aortic stenosis and ventricular remodeling.Sci. Robot.8, eade2184(2023).DOI:10.1126/scirobotics.ade2184
Through the development of a high-fidelity model of aortic stenosis and diastolic dysfunction, this work demonstrates the use of soft robotics to recreate cardiovascular disease, with potential applications in device development, procedural planning, and outcome prediction in industrial and clinical settings.
Verheyen, C.A., Uzel, S.G.M., Kurum, A., Roche, E.T., Lewis, J.A. Integrated data-driven modeling and experimental optimization of granular hydrogel matrices,
Matter (2023), https://doi.org/10.1016/j.matt.2023.01.011
Hu, L., Bonnemain, J., Saeed, M.Y.,Singh, M.,Quevedo Moreno, D., Vasilyev, N.V., Roche, E.T. An implantable soft robotic ventilator augments inspiration in a pig model of respiratory insufficiency. Nat. Biomed. Eng (2022). https://doi.org/10.1038/s41551-022-00971-6
K. Mendez, D. G. O'Neill, D. D. Wang, B. O'Neill, E.T. Roche, "Left Atrial Appendage Occlusion: Current Stroke Prevention Strategies and a Shift Toward Data-Driven, Patient-Specific Approaches", Journal of the Society for Cardiovascular Angiography & Interventions, 2022, doi: https://doi.org/10.1016/j.jscai.2022.100405
L. Rosalia, C. Ozturk, J. Coll-Font, Y. Fan, Y. Nagata, M. Singh, D. Goswami, A. Mauskapf, S. Chen, R. A. Eder, E. M. Goffer, J. H. Kim, S. Yurista, B. P. Bonner, A. N. Foster, R. A. Levine, E. R. Edelman, M. Panagia, J. L. Guerrero, E. T. Roche, C. T. Nguyen, "A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis", Nature Biomedical Engineering, 2022, doi: https://doi.org/10.1038/s41551-022-00937-8
W. Whyte, D. Goswami, S. X. Wang, Y. Fan, N. Ward, R. E. Levey, R. Beatty, S. T. Robinson, D. Sheppard, R. O’Connor, D. S. Monahan, L. Trask, K. L. Mendez, C. E. Varela, M. A. Horvath, R. Wylie, J. O’Dwyer, D. A. Domingo-Lopez, A. S. Rothman, G. P. Duffy, E. B. Dolan, E. T. Roche, "Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform", Nature Communications, Vol 13, August 2022, doi: https://doi.org/10.1038/s41467-022-32147-w
Park C, Ozturk C, Roche ET, "Computational Design of a Soft Robotic Myocardium for Biomimetic Motion and Function", Advanced Functional Materials, Vol 33, August 2022, doi: 0.1002/adfm.202206734
S. D. Gollob, J. Poss, G. Memoli and E. T. Roche, "A Multi-Material, Anthropomorphic Metacarpophalangeal Joint With Abduction and Adduction Actuated by Soft Artificial Muscles," in IEEE Robotics and Automation Letters, vol. 7, no. 3, pp. 5882-5887, July 2022, doi: 10.1109/LRA.2022.3161714.
Advances in Cardiovascular Technology - Luca, Mossab and Ellen wrote Chapter 38- Devices that enhance the Biomechanics of the Failing Heart https://www.sciencedirect.com/science/article/pii/B9780128168615000150
Bonnemain, J., del Nido, P. J., & Roche, E. T. (2022). Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function. Annual Review of Biomedical Engineering, 24(1), 137–156. https://doi.org/10.1146/annurev-bioeng-110220-025309
Ozturk C, Rosalia L and Roche ET (2022) A Multi-Domain Simulation Study of a Pulsatile-Flow Pump Device for Heart Failure With Preserved Ejection Fraction. Front. Physiol. 13:815787. doi:10.3389/fphys.2022.815787
M Das, KS Hahm, AA LaRocca, CA Luna, K Mendez, R Hoffman, C Verheyen, T G Kim, B W Wamakima, E Roche (2022). A Low-Cost, Easily Deployable Vesicovaginal Fistula Occluding Device for Providing Interim Continence. J. Med. Devices. Paper No: MED-21-1064. doi:10.1115/1.4053603.
Singh M, Park C and Roche ET (2022). Decellularization Following Fixation of Explanted Aortic Valves as a Strategy for Preserving Native Mechanical Properties and Function. Front. Bioeng. Biotechnol. 9:803183. doi: 10.3389/fbioe.2021.803183
L. Rosalia et al., "A Soft Robotic Sleeve for Compression Therapy of the Lower Limb," 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2021, pp. 1280-1283, doi: 10.1109/EMBC46164.2021.9630924.
Mendoza MJ, Gollob SD, Lavado D, Koo BH, Cruz S, Roche ET, Vela EA. A Vacuum-Powered Artificial Muscle Designed for Infant Rehabilitation. Micromachines. 2021 Aug;12(8):971. DOI: 10.3390/mi12080971
Yuk, H., Wu, J., Sarrafian, T.L. et al. Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue. Nat Biomed Eng 5, 1131–1142 (2021). https://doi.org/10.1038/s41551-021-00769-y
Rosalia L, Ozturk C, Shoar S, Fan Y, Malone G, Cheema FH, Conway C, Byrne RA, Duffy GP, Malone A, Roche ET. Device-Based Solutions to Improve Cardiac Physiology and Hemodynamics in Heart Failure With Preserved Ejection Fraction. JACC: Basic to Translational Science. 2021 Aug 4. DOI: 10.1016/j.jacbts.2021.06.002
L Rosalia, C Ozturk, Y Fan, J Coll-Font, S Chen, R Eder, J Kim, Y Nagata, R Levine, M Panagia, J Guerrero, A Mauskapf, ET Roche, C Nguyen, Recapitulating aortic valve disease hemodynamics with a highly tunable bio-inspired soft robotic aortic sleeve, Preprint under consideration at a Nature Portfolio Journal, 22 July 2021, doi: 10.21203/rs.3.rs-713582/v1
D Goswami, DA Domingo-Lopez, N Ward, J Millman, GP Duffy, EB Dolan, ET Roche, Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes, Advanced Science, 21 June 2021, doi: https://doi.org/10.1002/advs.202100820
Y Fan, J Coll-Font, M ven den Boomen, JH Kim, S Chen, RA Edar, ET Roche, C Nguyen, Characterization of Exercise-Induced Myocardium Growth Using Finite Element Modeling and Bayesian Optimization, Frontiers in Physiology, 19 July 2021, doi: 10.3389/fphys.2021.694940
Mijaíl Jaén Mendoza, Samuel Dutra Gollob, Diego Lavado, Bon Ho Brandon Koo, Segundo Cruz, Ellen T. Roche, Emir A. Vela. A Vacuum-Powered Artificial Muscle Designed for Infant Rehabilitation, Micromachines 2021, 12(8), 971; https://doi.org/10.3390/mi12080971
O Byrne , F Coulter, ET Roche, ED O'Cearbhaill. In silico design of additively manufacturable composite synthetic vascular conduits and grafts with tuneable compliance. Biomater Sci. 2021 Jun 15; 9(12):4343-4355. PMID: 33724267.
L. Ricotti, T. Fuhie, E.T. Roche. “Guest Editorial: Bionic Organs and Tissues”. IEEE Robotics and Automations Systems, Transactions on Medical Robotics and Bionics.
L Hu, D Gau, J Dixon, M Klein, Y Fan, G Menary, ET Roche, Precurved, Fiber-Reinforced Actuators Enable Pneumatically Efficient Replication of Complex Biological Motions, Soft Robotics (SoRo), 17 May 2021 DOI: 10.1089/soro.2020.0087
M Singh, C Varela, W Whyte, M Horvath, NCS Tan, C Ong, P Liang, M Schermerhorn, ET Roche, TWJ Steele, Minimally invasive electroceutical catheter for endoluminal defect sealing, Science Advances, 2 April 2021, doi: doi.org/10.1126/sciadv.abf6855
S. Maglio, C. Park, S. Tognarelli, A. Menciassi, E. T. Roche, High-Fidelity Physical Organ Simulators: From Artificial to Bio-Hybrid Solutions, IEEE Transactions on Medical Robotics and Bionics, 04 Mar 2021 DOI: 10.1109/TMRB.2021.3063808
Gollob SD, Park C, Koo BH, Roche ET. A Modular Geometrical Framework for Modelling the Force-Contraction Profile of Vacuum-Powered Soft Actuators. Frontiers in Robotics and AI. 2021 Mar 03; 8:15. DOI: 10.3389/frobt.2021.606938
L. Rosalia, C Ozturk, ET Roche, Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction, Journal of Visualized Experiments (JoVE), 13 February 2021, DOI: 10.3791/62167
Luca Rosalia, Caglar Ozturk, David Van Story, Markus Horvath, Ellen T Roche, Object-oriented lumped-parameter modeling of the cardiovascular system for physiological and pathophysiological conditions, Advanced Theory and Simulations, 12 February 2021: Vol. 4, Issue 2, doi: https://doi.org/10.1002/adts.202000216
Roche, Ellen T. A protein sandwich enables real-time in vivo biomarker measurement, Science Translational Medicine 06 Jan 2021: Vol. 13, Issue 575, eabg1758, DOI: 10.1126/scitranslmed.abg1758 Editors Choice Article Link
H Yuk, J Wu, X Mao, CE Varela, ET. Roche, CS Nabzdyk, X Zhao, Barnacle-Inspired Paste for Instant Hemostatic Tissue Sealing, BioRxiV, 12 December 2020, doi: doi.org/10.1101/2020.12.12.422505
Roche, Ellen T. Encapsulating a leukemia vaccine, Science Translational Medicine 28 Oct 2020: Vol. 12, Issue 567, eabf2642 DOI: 10.1126/scitranslmed.abf2642 Link
Roche, Ellen T. Catheters gain arrays of sensors and actuators, Nature Biomedical Engineering, 22 October 2020, Volume 4, pages 939-940. Link
Deng J, Yuk H, Wu J, Varela CE, Chen X, Roche ET, Guo CF, Zhao X. Electrical bioadhesive interface for bioelectronics. Nature Materials. 2020 Sep 28:1-8. DOI:10.1038/s41563-020-00814-2
Roche ET, Shedding light on heart failure, Science Translational Medicine, 02 Sep 2020: Vol. 12, Issue 559, eabe4436 DOI: 10.1126/scitranslmed.abe443
Roche ET, Minimally Invasive Delivery of Tissue Engineered Heart Valves to the Pulmonary Annulus, JACC: Basic to Translational Science, 5;8;2020, DOI: 10.1016/j.jacbts.2020.07.001
Roche ET, Paving the path to inpatient printing, Science Translational Medicine 08 Jul 2020:Vol. 12, Issue 551, eabd3082, DOI: 10.1126/scitranslmed.abd3082
Duffy GP, Robinson ST, O'Connor R, Wylie R, Mauerhofer C, Bellavia G, Straino S, Cianfarani F, Mendez K, Beatty R, Levey R, Duffy GP, Roche ET*, Dolan EB* .Therapeutic Reservoirs: Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models. Advanced Healthcare Materials. 2020 Jun 10;9(11):2070035. DOI: 10.1002/adhm.202070035 (*co-senior authors).
Horvath MA, Hu L, Mueller T, Hochstein J, Rosalia L, Hibbert KA, Hardin CC, Roche ET. An organosynthetic soft robotic respiratory simulator. APL Bioengineering. 2020 Jun 1;4(2):026108. DOI: 10.1063/1.5140760
Roche ET. Shedding light on venous thromboembolism, Science Translational Medicine, 13 May 2020:Vol. 12, Issue 543, eabb7098, DOI: 10.1126/scitranslmed.abb7098
Roche ET. Not “dust” any neural stimulator. Science Translational Medicine. 2020 Mar 18;12(535). DOI: 10.1126/scitranslmed.abb2775
Park C, Fan Y, Hager G, Yuk H, Singh M, Rojas A, Hameed A, Saeed M, Vasilyev NV, Steele TW, Zhao X, Nguyen CT*, Roche ET*. An organosynthetic dynamic heart model with enhanced biomimicry guided by cardiac diffusion tensor imaging. Science Robotics. 2020 Jan 29;5(38). DOI: 10.1126/scirobotics.aay9106.
Cobi AC, Gray L, Mittmann ER, Link SB, Hanumara NC, Lyatskaya Y, Roche E, Slocum AH, Zygmanski P. Design of a Reconfigurable Quality Assurance Phantom for Verifying the Spatial Accuracy of Radiosurgery Treatments for Multiple Brain Metastases. Journal of Medical Devices. 2019 Dec 1;13(4). DOI: 10.1115/1.4044402
Yuk H*, Varela CE*, Nabzdyk CS, Mao X, Padera RF, Roche ET, Zhao X. Dry double-sided tape for adhesion of wet tissues and devices. Nature. 2019 Nov;575(7781):169-74. DOI: /10.1038/s41586-019-1710-5 (*co-first authors).
Fan Y, Ronan W, Teh I, Schneider JE, Varela CE, Whyte W, McHugh P, Leen S, Roche E. A comparison of two quasi‐static computational models for assessment of intra‐myocardial injection as a therapeutic strategy for heart failure. International Journal for Numerical Methods in Biomedical Engineering. 2019 Sep;35(9):e3213. DOI: 10.1002/cnm.3213
Weafer FM, Duffy S, Machado I, Gunning G, Mordasini P, Roche E, McHugh PE, Gilvarry M. Characterization of strut indentation during mechanical thrombectomy in acute ischemic stroke clot analogs. Journal of neurointerventional surgery. 2019 Sep 1;11(9):891-7. DOI: 10.1136/neurintsurg-2018-014601
Dolan EB, Varela CE, Mendez K, Whyte W, Levey RE, Robinson ST, Maye E, O’Dwyer J, Beatty R, Rothman A, Fan Y. An actuatable soft reservoir modulates host foreign body response. Science Robotics. 2019 Aug 28;4(33):eaax7043. DOI: 10.1126/scirobotics.aax7043
Shirazi RN, Islam S, Weafer FM, Whyte W, Varela CE, Villanyi A, Ronan W, McHugh P, Roche ET. Multiscale Experimental and Computational Modeling Approaches to Characterize Therapy Delivery to the Heart from an Implantable Epicardial Biomaterial Reservoir. Advanced healthcare materials. 2019 Aug 22;8(16):1900228. DOI: 10.1002/adhm.201900228
Varela CE, Fan Y, Roche ET. Optimizing Epicardial restraint and reinforcement following myocardial infarction: Moving towards localized, biomimetic, and multitherapeutic options. Biomimetics. 2019 Mar;4(1):7. DOI: 10.3390/biomimetics4010007
Roche ET. Implanted device enables responsive bladder control. Nature. 2019 Jan 1;565(7737):298-. DOI: 10.1038/d41586-018-07811-1
*Horvath MA, *Varela CE, *Dolan EB, Whyte W, Monahan DS, Payne CJ, Wamala IA, Vasilyev NV, Pigula FA, Mooney DJ, Walsh CJ, Roche ET. Towards alternative approaches for coupling of a soft robotic sleeve to the heart. Annals of biomedical engineering. 2018 Oct 15;46(10):1534-47. DOI: 10.1007/s10439-018-2046-2 (*co-first authors)
Whyte W*, Roche ET*, Varela CE, Mendez K, Islam S, O’Neill H, Weafer F, Shirazi RN, Weaver JC, Vasilyev NV, McHugh PE, Murphy B, Duffy GP, Walsh CJ**, Mooney DJ**. Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir. Nature biomedical engineering. 2018 Jun;2(6):416. DOI: 10.1038/s41551-018-0247-5. (*co-first authors, **co-senior authors)
Wamala I, Roche ET, Pigula FA. The use of soft robotics in cardiovascular therapy. Expert review of cardiovascular therapy. 2017 Oct 3;15(10):767-74. DOI: 10.1080/14779072.2017.1366313
Payne CJ, Wamala I, Abah C, Thalhofer T, Saeed M, Bautista-Salinas D, Horvath MA, Vasilyev NV, Roche ET, Pigula FA, Walsh CJ. An implantable extracardiac soft robotic device for the failing heart: mechanical coupling and synchronization. Soft robotics. 2017 Sep 1;4(3):241-50. DOI: 10.1089/soro.2016.0076
Horvath MA, Wamala I, Rytkin E, Doyle E, Payne CJ, Thalhofer T, Berra I, Solovyeva A, Saeed M, Hendren S, Roche ET. An intracardiac soft robotic device for augmentation of blood ejection from the failing right ventricle. Annals of biomedical engineering. 2017 Sep 1;45(9):2222-33. DOI: 10.1007/s10439-017-1855-z
Roche ET, Horvath MA, Wamala I, Alazmani A, Song SE, Whyte W, Machaidze Z, Payne CJ, Weaver JC, Fishbein G, Kuebler J. Soft robotic sleeve supports heart function. Science translational medicine. 2017 Jan 18;9(373):eaaf3925. DOI: 10.1126/scitranslmed.aaf3925
O'Neill HS, Gallagher LB, O'Sullivan J, Whyte W, Curley C, Dolan E, Hameed A, O'Dwyer J, Payne C, O'Reilly D, Ruiz‐Hernandez E. Biomaterial‐enhanced cell and drug delivery: lessons learned in the cardiac field and future perspectives. Advanced materials. 2016 Jul;28(27):5648-61. DOI: 10.1002/adma.201505349
Cezar CA, Roche ET, Vandenburgh HH, Duda GN, Walsh CJ, Mooney DJ. Biologic-free mechanically induced muscle regeneration. Proceedings of the National Academy of Sciences. 2016 Feb 9;113(6):1534-9. DOI: 10.1073/pnas.1517517113
Roche ET, Fabozzo A, Lee Y, Polygerinos P, Friehs I, Schuster L, Whyte W, Berazaluce AM, Bueno A, Lang N, Pereira MJ. A light-reflecting balloon catheter for atraumatic tissue defect repair. Science Translational Medicine. 2015 Sep 23;7(306):306ra149-. DOI: 10.1126/scitranslmed.aaa2406
Hastings CL, Roche ET, Ruiz-Hernandez E, Schenke-Layland K, Walsh CJ, Duffy GP. Drug and cell delivery for cardiac regeneration. Advanced drug delivery reviews. 2015 Apr 1;84:85-106. DOI: 10.1016/j.addr.2014.08.006
Roche ET, Hastings CL, Lewin SA, Shvartsman DE, Brudno Y, Vasilyev NV, O'Brien FJ, Walsh CJ, Duffy GP, Mooney DJ. Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart. Biomaterials. 2014 Aug 1;35(25):6850-8. DOI: 10.1016/j.biomaterials.2014.04.114
Isakov A, Murdaugh KM, Burke WC, Zimmerman S, Roche E, Holland D, Einarsson JI, Walsh CJ. A new laparoscopic morcellator using an actuated wire mesh and bag. Journal of Medical Devices. 2014 Mar 1;8(1). DOI: 10.1115/1.4026294
Roche ET, Wohlfarth R, Overvelde JT, Vasilyev NV, Pigula FA, Mooney DJ, Bertoldi K, Walsh CJ. A bioinspired soft actuated material. Advanced Materials. 2014 Feb;26(8):1200-6. DOI: 10.1002/adma.201304018
Wan Q, Schoppe O, Gunasekaran S, Holland D, Roche E, Hur HC, Walsh C. Multifunctional Laparoscopic Trocar With Built-in Fascial Closure and Stabilization. Journal of Medical Devices. 2013 Sep 1;7(3). DOI: 10.1115/1.4024478
Pardo-Martin C, Duffy M, Hoffman K, Poddar R, Holland D, Roche E, Walsh C, Loughlin K. Minimally Invasive Device for Rapid Urethrovesical Anastomosis. Journal of Medical Devices. 2013 Sep 1;7(3). DOI: 10.1115/1.4024503
Frech AJ, Orozco D, Davoudi K, Ding C, Field R, Yasin R, Roche E, Holland D, Walsh C. Laparoscopic Device for Direct and Indirect Suction. Journal of Medical Devices (technical brief). 2013 Sep 1;7(3). DOI: 10.1115/1.4024519
O'Flynn PM, Roche ET, Pandit AS. Generating an ex vivo vascular model. Asaio Journal. 2005 Jul 1;51(4):426-33. DOI: 10.1097/01.mat.0000170629.92765.bb
Teodorescu DL, Reeves CA, McGarel S, Mehra M, Roche ET. “Modulating Left Ventricular Assist Device Driveline Exit Site Biomechanics: A Systematic Approach To Achieving Percutaneous Implant Forgettability”, American Society of Artificial Internal Organs 66th Annual Conference. Virtual Meeting.
Horvath MA, Hu L, Mueller T, Roche ET. “Design and Fabrication of an In Vitro Model of Human Respiration Based on Soft Biomimetic Mechanisms”. 3rd Institute for Electrical and Electronic Engineers International Conference on Soft Robotics (RoboSoft). Virtual Meeting.
Ozturk C, Rosalia L, Nguyen CT, Roche ET. “Computational Modeling of a Novel Soft Robotic Implant for Pressure Overload-Induced Heart Failure”. 3rd Institute for Electrical and Electronic Engineers International Conference on Soft Robotics (RoboSoft). Virtual Meeting.
Mendez K, Whyte W, Duffy GP, Roche ET. "SoftSwitch: A Soft Implantable Device for On/Off Drug Release". Hamlyn Symposium on Medical Robotics, London, England.
Park C, Roche ET. “Development of an Organosynthetic Left Ventricle”. American Society of Artificial Organs. San Francisco, CA.
Weafer F, Roche ET, McHugh PE, Gilvarry M. “Characterisation of Strut Indentation During Mechanical Thrombectomy in Acute Ischemic Stroke Clot Analogues”. Bioengineering in Ireland Conference, Belfast, Nothern Ireland.
Whyte W, Roche ET. “Therepi: An Implantable System Enabling Targeted Cardiac Therapy with a Replenishable, Epicardial Reservoir”. World Congress of Biomechanics. Dublin, Ireland.
Dolan EB, Horvath MA, Varela CE, Roche ET. “In Vivo Comparison of a Silicone and Mesh-Based Device-Tissue Interface for Extracardiac Devices”. World Congress of Biomechanics. Dublin, Ireland.
Hu L, Saaed M, Wamala I, Payne CJ, VanStory D, Roche ET, Vasilyev NV. “Development of a Foldable, Self-Assembling, Structural Brace for a Soft Robotic Assist Device. American Society of Artificial Organs Conference, Philadelphia, PA.
Fan Y, Ronan W, McHugh PE, Roche ET. “A Comparison of Two Dynamic Computational Models for Cardiac Mechanics and Assessment of Intra-Myocardial Injection as a Therapeutic Strategy for Heart Failure”. World Congress of Biomechanics. Dublin, Ireland.
Weafer F, Mc Hugh PE, Roche ET. Therapy transport into ischemic heart tissue from an implantable therapy reservoir device. European Advanced Materials Congress, Stockholm. 2017 Aug 22. Winner of International Association of Advanced Materials Scientist Medal, 2017 area of ‘Biomaterials and Biodevices’
Payne CJ, Wamala I, Abah C, Thalhofer T, Saeed M, Bautista-Salinas D, Horvath MA, Vasilyev NV, Roche ET, Pigula FA, Walsh CJ. Wearable Soft Robotic Device Supports the Failing Heart in vivo. Hamlyn Symposium on Medical Robotics. 2017 Jun 25 (p. 37). DOI: 10.31256/hsmr2017.19
Weafer F, Roche ET, McHugh P, Gilvarry M. Characterisation of Strut Indentation during Mechanical Thrombectomy in Acute Ischemic Stroke Clot Analogues. Bioengineering in Ireland Conference, Belfast. 2017 Jan 20.
Roche ET, Shirazi RN, Weafer F, McHugh PE. Computational Modelling of Therapy Pharnacokinetics into Ischemic Heart Tissue from an Implantable Reservoir Delivery System. Bioengineering in Ireland Conference, Belfast. 2017 Jan 20
Whyte W, Roche ET, O'Neill H, Duffy GP, Walsh CJ, Mooney DJ. A Replenishable Cell Delivery System for the Heart. 4th TERMIS World Congress, Tissue Engineering Part A. 2015 Sep 1;21(S1):S-1. DOI: 10.1089/ten.tea.2015.5000.abstracts
Roche ET, Horvath MA, Alazmani A, Galloway KC, Vasilyev NV, Mooney DJ, Pigula FA, Walsh CJ. Design and fabrication of a soft robotic direct cardiac compression device. ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference 2015 Aug 5. American Society of Mechanical Engineers Digital Collection.
Horvath MA, Roche ET, Vogt DM, Mooney DJ, Pigula FA, Walsh CJ. Soft pressure sensing sleeve for direct cardiac compression device. ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference 2015 Aug 5. American Society of Mechanical Engineers Digital Collection. DOI: 10.1115/DETC2015-47567
Fabozzo A*, Roche ET*, Lee Y, Polygerinos P, Friehs I, Schuster L, Casar Berazaluce AM, Bueno A, Lang N, Pereira M, Feins E, Wassermann S, O’Cearbhaill ED, Vasilyev NV, Mooney DJ, Karp JM, del Nido, PJ, Walsh CJ. Enabling minimally invasive atraumatic repair of intracardiac septal defects with light. American Association for Thoracic Surgery (AATS) Annual Meeting. 2015 Jul. (*co-first author)
Roche ET, Wamala I, Horvath M, Song, SE, Vasilyev NV, Machaidze Z, Mooney DJ, Walsh CJ, Pigula FA. Soft Robotic Synchronized Actuation Improves Cardiac Output in a Porcine Model of Heart Failure. Harvard Medical School Research Day, Boston. 2015 May.
Hameed A, Hastings C, Roche E, O'Brien F, Walsh C, Mooney D, Duffy G. Advanced Materials For Cardiac Regeneration (AMCARE): Improving Stem Cell Delivery to the Infarcted Heart Using Biomaterial Approaches. Irish Journal of Medical Science 2014 Sep 1 (Vol. 183, pp. S246-S246).
Roche ET, Hastings CL, Lewin SA, Shvartsman D, Brudno YB, Walsh CJ, O’Brien FJ, Duffy GP, Mooney DJ. The promise of biomaterials for improving retention of cells in the infarcted heart. Cell research foundation conference on cell therapy for cardiovascular disease. 2014 Jan. (oral presentation)
Roche ET, Wohlfarth R, Overvelde JTB, Vasilyev NV, Pigula FA, Mooney DJ, Bertoldi K, Walsh CJ. A Bioinspired Soft Actuated Material. Materials Research Society, Fall Meeting. 2013 Nov.
Roche ET, Hastings CL, Lewin SA, Shvartsman D, Brudno YB, Walsh CJ, O’Brien FJ, Duffy GP,Mooney DJ. Biomaterials improve retention of cells in the infarcted heart. AHA Conference and abstract in Circulation 2013 Nov 26; 128: A18338
Roche ET, Menz A, Hiremath P, Vasilyev N, Walsh C. Design and fabrication of a soft, anatomically accurate, patient-specific cardiac simulator with sensing and controls. International Workshop on Soft Robotics and Morphological Computation, Switzerland. 2013 Aug.
Obiajulu SC, Roche ET, Pigula FA, Walsh CJ. Soft pneumatic artificial muscles with low threshold pressures for a cardiac compression device. ASME 2013 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference 2013 Aug 4. American Society of Mechanical Engineers Digital Collection. DOI: 10.1115/DETC2013-13004
Orozco D, Davoudi K, Ding C, Field R, Yasin R, Roche ET, Holland D, Walsh CJ. Laparoscopic tool with adjustable sponge at distal tip for direct/indirect suction modulation. Journal of Medical Devices (technical brief). 2013; 7(3):030908-030908-3.MED-13-1044.
Murdaugh K, Isakov A, Burke WC, Zimmerman S, Roche ET, Holland D, Einarsson JI, Walsh CJ. Faster and Safer Laparoscopic Morcellation Using an Actuated Wire Mesh and Bag. ASME Design of Medical Devices Conference (extended abstract, poster), Minneapolis, Minnesota, USA. 2013 Apr 9-11
Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey M. Karp, Yuhan Lee, Pedro J. Del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman. "Catheter Device for Transmitting and Reflecting Light " US Patent No. US10,588,695
Clara Park, Xuanhe Zhao, Hyunwoo Yuk, Christopher T. Nguyen, Ellen T. Roche. "An Organosynthetic Dynamic Heart Model", Provisional Patent Application 63/021,014
US Patent 10,058,647 B2 (grant) Biomimetic actuation device and system andmethods for controlling a biomimetic actuation device and system. Issued August 28th 2018.
Ellen T. Roche, Steven Obiajulu, Conor J. Walsh, David J. Mooney, Frank A. Pigula. "Biomimetic Actuation Device and System, and Methods for Controlling a Biomimetic Actuation Device and System", US Patent No. US10058647B2
Christine A. Cezar, Conor J. Walsh, David J. Mooney, Ellen T. Roche, Herman H. Vandenburgh, Georg N. Duda. "Compositions and Methods of Mechanically Inducing Tissue Regeneration", US National Phase Application PCT/US2016/062685
Ellen T. Roche, Kevin O'Sullivan. "Perfusion Dilation Catheter System and Methods of Use", US Patent No. US9480823B2
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