By providing dynamic assistance to failing organs we hope to augment their function. We look to nature to inspire structural design of implantable devices and use active or passive materials with mechanical properties similar to that of native tissue in order to provide atraumatic augmentation of function.
Hu L, Bonnemain J, Saeed M, Singh M, Vasilyev NV, Roche ET. An implantable ventilator augments inspiration in an in vivo porcine model https://doi.org/10.21203/rs.3.rs-1182615/v1
Park C, Ozturk C, Roche ET, "Computational Design of a Soft Robotic Myocardium for Biomimetic Motion and Function", Advanced Functional Materials, Vol 33, August 2022, doi: 10.1002/adfm.202206734
Roche ET, Horvath MA, Wamala I, Alazmani A, Song SE, Whyte W, Machaidze Z, Vasilyev NV, Mooney DJ, Pigula FA, and Walsh CJ. Soft Robotic Sleeve Restores Heart Function. Science Translational Medicine 2017 http://stm.sciencemag.org/content/9/373/eaaf3925
Horvath MA, Varela CE, Dolan EB, Whyte W, Monahan DS, Payne CJ, Wamala IA, Vasilyev NV, Pigula FA, Mooney DJ, Walsh CJ, Duffy GP, Roche ET. Towards Alternative Approaches for Coupling of a Soft Robotic Sleeve to the Heart. Ann Biomed Eng, 2018. https://doi.org/10.1007/s10439-018-2046-2